Progress in laboratory testing of thyroid disease

Research

Standardisation and harmonisation of thyroid-stimulating hormone measurements: historical, current, and future perspectives

Cowper B, Lyle AN, Vesper HW, Van Uytfanghe K, Burns C. Clin Chem Lab Med. 2024 - doi: 10.1515/cclm-2023-1332. Epub ahead of print

WHO 4th International Standards for TSH (human, pituitary)

WHO REFERENCE NUMBER: WHO/BS/2023.2454

Thyroid Stimulating Hormone and Thyroid Hormones (Triiodothyronine and Thyroxine): An American Thyroid Association-Commissioned Review of Current Clinical and Laboratory Status

Van Uytfanghe K, Ehrenkranz J, Halsall D, Hoff K, Loh TP, Spencer CA, Köhrle J. Thyroid. 2023;33:1013-1028.

Practical considerations for accurate determination of free thyroxine by equilibrium dialysis

Ribera A, Zhang L, Ribeiro C, Vazquez N, Thonkulpitak J, Botelho JC, Danilenko U, van Uytfanghe K, Vesper HW. J Mass Spectrom Adv Clin Lab 2023;29:9-15.

Description and validation of an equilibrium dialysis ID-LC-MS/MS candidate reference measurement procedure for free thyroxine in human serum

Jansen HI, van der Steen R, Brandt A, Olthaar AJ, Vesper HW, Shimizu E, Heijboer AC, Van Uytfanghe K, van Herwaarden AE. Clin Chem Lab Med 2023;61:1605-1611.

Development of an equilibrium dialysis ID-UPLC-MS/MS candidate reference measurement procedure for free thyroxine in human serum

Ribera A, Zhang L, Dabbs-Brown A, Sugahara O, Poynter K, van Uytfanghe K, Shimizu E, van Herwaarden AE, Botelho JC, Danilenko U, Vesper HW. Clin Biochem 2023;116:42-51.

Clinical Interpretation of Thyroid Tests: Considerations for Reference Intervals

Loh TP, Ehrenkranz J, Halsall D, Spencer CA, Van Uytfanghe K, Köhrle J. Thyroid 2023;33:404-406.

Implementing reference systems for thyroid function tests - A collaborative effort

Vesper HW, Van Uytfanghe K, Hishinuma A, Raverot V, Patru MM, Danilenko U, van Herwaarden AE, Shimizu E. Clin Chim Acta 2021;519:183-186.

Summary of activities to collect information about concerns and potential risks associated with changes in reference intervals for free thyroxine and TSH and about communication and interactions among relevant stakeholders

The C-STFT under the leadership Prof. Linda Thienpont, Dr. Jim Faix, and Dr. Graham Beastall performed broad initiatives world-wide to create awareness about harmonization and standardization of TSH and fT4 assays among assay manufacturers, clinical laboratories, endocrinologists, physicians, and patients. The C-STFT collected information from these stakeholders from 2014-2016 on how changes in assay calibration are communicated to laboratories and physicians, on concerns by...

Seasonal changes in serum TSH concentrations observed from a big dataset obtained during 6 consecutive years from 2010 to 2015 at a single hospital in Japan.

Yoshihara A, Noh J, Watanabe N, Iwaku K, Kunii Y, Ohye H, Suzuki M, Matsumoto M, Suzuki N, Sugino K, Thienpont L, Hishinuma A, Ito K. Thyroid 2018;28:429-436.

Standardization of free thyroxine measurements paves the way for the adoption of a more uniform reference interval

De Grande LAC, Van Uytfanghe K, Reynders D, Das B, Faix JD, MacKenzie F, Decallonne B, Hishinuma A, Lapauw B, Taelman P, Van Crombrugge P, Van den Bruel A, Velkeniers B, Williams P, Thienpont LM on behalf for the IFCC Committee for Standardization of Thyroid Function Tests (C-STFT). Clin Chem 2017;63:1642-52.

Harmonization of serum thyroid-stimulating hormone measurements paves the way for the adoption of a more uniform reference interval.

Thienpont LM, Van Uytfanghe K, De Grande LAC, Reynders D, Das B, Faix JD, MacKenzie F, Decallonne B, Hishinuma A, Lapauw B, Taelman P, Van Crombrugge P, Van den Bruel A, Velkeniers B, Williams P on behalf for the IFCC Committee for Standardization of Thyroid Function Tests (C-STFT). Clin Chem 2017;63:1248-60.

Using "big data" to describe the effect of seasonal variation in thyroid-stimulating hormone.

De Grande LA, Goossens K, Van Uytfanghe K, Halsall I, Yoshimura Noh J, Hens K, Thienpont LM. Clin Chem Lab Med 2017;55:e34-e36.

Monitoring the stability of the standardization status of FT4 and TSH assays by use of daily outpatient medians and flagging frequencies.

De Grande LA, Goossens K, Van Uytfanghe K, Das B, MacKenzie F, Patru MM, Thienpont LM; IFCC Committee for Standardization of Thyroid Function Tests (C-STFT). Clin Chim Acta. 2017;467:4-18.

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